
The smallpox vaccine is known for leaving a permanent scar on the upper arm. The scar is typically round with irregular edges and is slightly lower than the surrounding skin. This scar is a result of the body's natural healing process as it rapidly repairs the injured skin. The smallpox vaccine is no longer commonly administered, so the scar is far less common than it used to be. However, another vaccine that leaves a similar scar is the Bacille Calmette-Guérin (BCG) vaccine, which is used to protect against tuberculosis. This vaccine is frequently administered in countries with higher TB rates and often leaves a scar with a raised center and rounded edges.
| Characteristics | Values |
|---|---|
| Vaccine Name | Smallpox, Bacille Calmette-Guérin (BCG) |
| Who Receives It | People born outside the U.S. receive the BCG vaccine |
| Age Group | People over 40 are likely to have a smallpox vaccine scar |
| Vaccine Type | The smallpox vaccine is given using a bifurcated (two-prong) needle |
| Number of Doses | The smallpox vaccine is delivered in a two-dose series |
| Complications | The smallpox vaccine can cause a permanent scar in the cornea |
| Scar Appearance | The smallpox vaccine scar is round, oval, or circular and about the size of a dime |
| Scar Location | Upper arm |
| Scar Treatment | Sunscreen, moisturizer, scar cream, and skin camouflage creams |
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What You'll Learn
- Smallpox vaccine scars are a sign of a successful immune response
- The BCG vaccine leaves a similar scar but protects against tuberculosis
- The ACAM2000 smallpox vaccine uses a two-pronged needle to cause a controlled infection
- The smallpox vaccine hasn't been widely distributed since 1972, so younger people likely have a BCG scar
- The smallpox vaccine is no longer necessary but left a lasting mark on global health

Smallpox vaccine scars are a sign of a successful immune response
The smallpox vaccine was a major medical achievement, helping to eradicate smallpox globally by 1980. The vaccine was highly effective, with a fatality rate of around 30% for those who contracted the disease. However, the vaccine was delivered in a unique manner compared to other vaccines. Instead of a single puncture, the smallpox vaccine was administered using a two-pronged needle to make multiple punctures in the skin, delivering the virus to the skin's dermis. This technique caused a controlled infection, stimulating the immune system to build its defences.
The scar is a result of the body's natural healing process. When the skin is injured, the body rapidly repairs the tissue, but the result is scar tissue, which has skin fibres arranged in a single direction, unlike normal skin. This scar tissue grows more quickly than normal skin cells, leaving a visible reminder of the injury. For some people, the smallpox vaccine scar is a small reminder of the successful global immunization effort to eradicate a deadly disease.
While the smallpox vaccine is no longer routinely administered, some people may still receive it due to their line of work. Certain military service members and laboratory workers may still be given the vaccine. Additionally, there was a recent recommendation by the CDC to consider using the ACAM2000 smallpox vaccine to control monkeypox. However, it is important to note that the smallpox vaccine does not protect against monkeypox, and the JYNNEOS vaccine is available for that purpose without causing skin lesions or scarring.
It is worth mentioning that not all arm scars are from smallpox vaccines. The Bacille Calmette-Guérin (BCG) vaccine for tuberculosis also leaves a similar scar. This vaccine is commonly administered at birth in many countries outside the US, where tuberculosis rates are higher. Thus, it is important to distinguish between the two types of scars, as the smallpox vaccine scar indicates exposure to the smallpox vaccine, while the BCG vaccine scar indicates tuberculosis protection.
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The BCG vaccine leaves a similar scar but protects against tuberculosis
The smallpox vaccine, which was common in the past, leaves a small scar on the upper arm. However, due to the eradication of smallpox, the vaccine is no longer widely administered, making the scar less common nowadays.
The Bacille Calmette-Guérin (BCG) vaccine, which is primarily used for vaccination against tuberculosis (TB), also leaves a scar on the arm. The BCG vaccine is typically administered at birth or during early childhood in many countries outside the US. It is injected into the skin, often in the upper part of the left arm, leaving a small ulcer that heals with some scarring. The scar is often used to confirm vaccination, especially in countries with high rates of TB.
While the BCG vaccine is effective in preventing severe forms of TB, its efficacy varies depending on geographical location and the laboratory in which the vaccine strain was grown. Clinical trials have shown inconsistent results, with some indicating a protective effect of up to 80%, while others have shown no protective effect. The variable efficacy may be attributed to factors such as genetic differences in populations and changes in the environment.
It is important to note that the BCG scar does not guarantee protection against TB. A Mantoux skin test or Tuberculin Skin Test (TST) is often used to confirm the immune response after vaccination. This test involves injecting a small amount of TB protein under the skin and measuring the body's reaction. A positive result indicates a potential TB infection or a strong immune response to the vaccine.
In summary, the BCG vaccine leaves a scar on the arm and provides protection against tuberculosis, with its effectiveness varying across different regions and populations.
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The ACAM2000 smallpox vaccine uses a two-pronged needle to cause a controlled infection
The smallpox vaccine is a small mark that people born before 1972 may have on their upper arm if they received the Dryvax or ACAM2000 smallpox vaccines. The scar is a sign that the vaccine successfully spurred an immune response in the body to protect against smallpox. The smallpox vaccine is no longer common, and the scar is far less common than it used to be.
The ACAM2000 smallpox vaccine uses a two-pronged needle to cause a small, controlled infection in the skin. The two-pronged needle is dipped into the vaccine solution and the skin is pricked multiple times in the upper arm with a droplet of the vaccine. The vaccine is made from a "pox"-type virus called vaccinia, which is related to smallpox but causes a milder disease. ACAM2000 does not contain the smallpox virus, but rather the "live" vaccinia virus.
The multiple punctures in the skin cause a minor, localized infection or "pock" to form. This infection spurs the body's immune system to build up its defences. A red, itchy sore spot at the site of the vaccination within 3-4 days is an indicator that the vaccination was successful.
The ACAM2000 vaccine is different from the Dryvax vaccine, which was used in the global eradication of smallpox. Both vaccines are derived from the New York City Board of Health strain of vaccinia, but Dryvax was grown on the skin of calves and then freeze-dried for storage. ACAM2000 is administered differently from most other vaccines, which are typically injected with a standard needle.
While the smallpox vaccine is no longer common, the ACAM2000 vaccine is still relevant today as it has been recommended by the CDC as a vaccine to help control monkeypox.
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The smallpox vaccine hasn't been widely distributed since 1972, so younger people likely have a BCG scar
The smallpox vaccine was a major medical achievement, but it left behind a distinctive mark or scar on the upper arm. The vaccine was delivered using a bifurcated (two-pronged) needle that caused a small, controlled infection in the skin. This infection spurred the body's immune system to build up its defences, leaving behind a small scar.
The smallpox vaccine is no longer widely distributed since it was last administered in the US in 1972. The World Health Organization (WHO) declared smallpox eliminated worldwide in 1980 and stopped administering or promoting the vaccine. As a result, the smallpox vaccine scar is far less common than it used to be. If you are in your 40s or older, you likely have a smallpox vaccine scar from the Dryvax or ACAM2000 vaccines. However, it is highly unlikely that anyone under the age of 42 has received a smallpox vaccine.
The Bacille Calmette-Guérin (BCG) vaccine, which offers protection against tuberculosis (TB), is another vaccine that causes a similar scar on the upper arm. The BCG vaccine is not routinely given in the United States, as TB occurs at low rates. However, it is the most frequently administered vaccine worldwide and is commonly given at birth in many countries outside the US. The BCG scar tends to have a raised centre with rounded edges, whereas the smallpox vaccine scar is typically round or oval-shaped with irregular edges and may be slightly depressed with lines radiating outward.
It is important to note that having a scar from a smallpox vaccine does not mean you are still protected against smallpox. According to the CDC, the smallpox vaccine only provides full immunity for 3 to 5 years. Therefore, even those with a smallpox vaccine scar should not rely on it to remain active enough to protect them from smallpox now.
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The smallpox vaccine is no longer necessary but left a lasting mark on global health
The smallpox vaccine is no longer necessary for the general public, but it left a lasting mark on global health. Smallpox was a deadly disease that ravaged the world for thousands of years, killing hundreds of millions of people. The disease did not discriminate, infecting the rich, the poor, the young, and the old, with a mortality rate of at least 1 in 3 infected individuals. The symptoms were gruesome, including high fever, vomiting, mouth sores, and fluid-filled lesions all over the body. Death would often come suddenly, within 2 weeks, and survivors were often left with permanent disabilities such as blindness and infertility.
In the 18th century, variolation, or direct exposure to smallpox sores, was practiced as a form of immunization. This involved inhaling or rubbing material from smallpox sores into the skin, with the hope of causing a controlled infection that would confer future immunity. In 1796, British physician Edward Jenner demonstrated that infection with the milder cowpox virus provided immunity against smallpox. Cowpox served as a natural vaccine until the modern smallpox vaccine emerged in the 20th century.
The smallpox vaccine was the first vaccine developed against a contagious disease. It played a pivotal role in the worldwide eradication of smallpox. The World Health Organization (WHO) led a global vaccination campaign from 1958 to 1977, resulting in the elimination of smallpox in various regions. This massive international effort involved universal childhood immunization programs, mass vaccination drives, and targeted surveillance-containment strategies. The last endemic case of smallpox was identified in Somalia in October 1977, and the disease was officially declared eradicated in 1980.
The smallpox vaccine left a small scar on the upper arm, which was a sign that the vaccine had successfully spurred an immune response. The vaccine caused a minor, localized infection at the injection site, prompting the body's immune system to build up its defenses. The bump later blistered and dried up, leaving behind a permanent scar. While the smallpox vaccine is no longer routinely administered, it is still being produced for research and to guard against potential bioterrorism and biological warfare. The lasting mark of the smallpox vaccine on global health is a testament to the power of vaccination in eradicating deadly diseases.
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Frequently asked questions
The smallpox vaccine is known for leaving a scar on the upper arm. The Bacille Calmette-Guérin (BCG) vaccine, which is used to protect against tuberculosis, can also leave a similar scar.
The smallpox vaccine uses a two-pronged needle to cause a small, controlled infection in your skin. This minor infection spurs your body's immune system to build up its defences. The bump left by the needle later becomes a blister and leaves a permanent scar as it dries up.
The smallpox vaccine scar is typically round or oval-shaped, about the size of a dime, and may be lower than the surrounding skin.























