
Smallpox vaccine scars are small, round marks that appear on the upper arm. They are caused by the body's natural healing process, which involves rapidly repairing tissue and creating scar tissue. The smallpox vaccine was delivered using a two-pronged needle, which caused a small, controlled infection in the skin. This method is no longer common, so smallpox vaccine scars are rarer nowadays. However, similar scars can be left by the Bacillus Calmette-Guérin (BCG) vaccine, which is used to protect against tuberculosis. These scars can be differentiated from smallpox vaccine scars by their distinct characteristics.
| Characteristics | Values |
|---|---|
| Type of vaccination | Smallpox or tuberculosis |
| Age of people with the scar | 40 or older |
| Shape | Round or oval |
| Size | About the size of a dime |
| Location | Upper left arm |
| Depth | Deeper or lower than the surrounding skin |
| Edges | Irregular |
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What You'll Learn

Smallpox vaccine scars are rare today
The smallpox vaccine is considered a major medical achievement, but it leaves behind a distinctive mark or scar. The vaccine was delivered using a unique method: a two-pronged needle that made multiple punctures in the skin to deliver the virus to the dermis, the layer just below the epidermis. This caused a minor, localised infection that the body fought off, but the process left a small mark on the skin.
The smallpox vaccine has not been commonly administered since the 1970s, and smallpox itself was eradicated in the early 1980s. As a result, smallpox vaccine scars are now relatively rare. If you are in your 40s or older, you may have a permanent scar from an older version of the smallpox vaccine on your upper left arm. This is because the vaccine was typically given to people in this age group when they were children, and the scar is a sign that the vaccine successfully spurred an immune response.
The scar is generally round but may have irregular edges, and it may be slightly lower than the surrounding skin. It is usually smaller than the diameter of a pencil eraser but can be larger in some people who experience an inflammatory response to the injection. In some cases, the scar can be itchy or uncomfortable, which is a normal part of the body's response to scarring.
It's important to note that not everyone who received the smallpox vaccine has a visible scar. Additionally, a mark on the arm that resembles a smallpox vaccine scar could be from a different vaccine, such as the Bacille Calmette-Guérin (BCG) vaccine against tuberculosis. This vaccine also leaves a scar on the upper arm, but it protects against a different virus.
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The scar is a sign the vaccine worked
The smallpox vaccine was a major medical achievement, but it left behind a distinctive mark or scar on the upper arm. This scar is a sign that the vaccine successfully spurred an immune response in your body to protect you against smallpox.
The smallpox vaccine is delivered in a unique manner compared to many other vaccines. It is given using a special bifurcated (two-pronged) needle that makes multiple punctures in the skin to deliver the virus to the dermis, the layer just below the epidermis. This technique causes a minor, localised infection that your body fights off, but the process leaves behind a small mark where the infection occurred.
The scar is typically round or oval-shaped and about the size of a dime. It may look "deeper" or lower than the surrounding skin. The bump later develops into a vesicle, which looks like a fluid-filled blister. Ultimately, this blistered area will scab over and leave a permanent scar as it dries up.
The scar is a sign that the vaccine worked and that your body has built up defences against smallpox. This was particularly beneficial during the height of smallpox concerns, as health officials could assume a person was vaccinated against the virus simply by inspecting their arm for the presence of the scar.
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The Bacille Calmette-Guerin (BCG) vaccine also leaves a mark
The Bacille Calmette-Guerin (BCG) vaccine is a live attenuated strain of Mycobacterium bovis, first used in humans in 1921. It is one of the most widely used vaccines globally and is primarily administered to protect against human tuberculosis. The BCG vaccine is not generally used in the United States due to the low risk of infection with TB bacteria, variable effectiveness against adult pulmonary TB, and the potential for false-positive TB skin test results. However, it is routinely administered in many other countries, including Iran, South Africa, Morocco, Kenya, and Australia (until the mid-1980s).
The BCG vaccine is typically given as a single intradermal injection at the insertion of the deltoid, often in the upper arm. This injection can leave a distinctive mark or scar, similar in appearance to the smallpox vaccine scar. The BCG vaccine scar forms due to the body's natural healing process, as the skin tissue repairs itself after the minor controlled infection caused by the vaccine. The scar is usually small, round, and may have irregular edges, located a little lower than the surrounding skin.
The presence of a BCG vaccine scar is often used as proof of prior immunization. However, it is important to distinguish it from the smallpox vaccine scar, as they are two different vaccines protecting against different viruses. The smallpox vaccine is no longer commonly administered, but it was widely used during the height of smallpox concerns. The BCG vaccine scar tends to be located on the upper arm, resembling a dime-sized dent, while the smallpox vaccine scar is typically found on the upper left arm.
While the BCG vaccine is generally safe, it can cause some adverse reactions, such as local abscesses ("BCG-oma") if administered incorrectly. These abscesses may require treatment with antibiotics to prevent the spread of infection to vital organs. Other possible side effects include a red indurated area at the injection site, which may ulcerate and form a crust before healing, leaving a small scar. Management of these complications varies, and the optimal approach is still uncertain.
The BCG vaccine has also been studied for its potential benefits beyond tuberculosis prevention. There is tentative evidence suggesting that it may reduce overall mortality and improve protection against sepsis, respiratory infections, and COVID-19. Additionally, it has been used in the treatment of superficial carcinoma of the bladder and provides some protection against leprosy and non-tuberculous mycobacterial infections.
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The smallpox vaccine is no longer common
The smallpox vaccine was developed in 1796 by English doctor Edward Jenner. He noticed that milkmaids who had been infected with cowpox were protected from smallpox. To test his theory, Jenner inoculated 8-year-old James Phipps, the son of his gardener, with matter from a cowpox sore. Phipps reacted to the cowpox matter and felt unwell for several days but made a full recovery. Two months later, Jenner inoculated Phipps with matter from a human smallpox sore, and the boy remained in perfect health.
Jenner's vaccine was soon in use on other continents, and mandatory vaccination came into effect in Britain and parts of the United States in the 1840s and 1850s. The vaccine was administered using a two-pronged bifurcated needle, which made multiple punctures in the skin to deliver the virus to the dermis, the layer just below the epidermis. This technique caused a controlled infection that forced the body to build up its defences.
The smallpox vaccine left a distinctive scar, and during the height of smallpox concerns, having this mark was beneficial as it indicated that a person was vaccinated against the virus. However, with the eradication of smallpox, the vaccine is no longer common, and neither is the scar. While the smallpox vaccine is no longer needed, it did lay the foundation for modern immunology, and its development was a major medical achievement.
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The scar is a reminder of a grand global achievement
The smallpox vaccine was a major medical achievement, and the scar it left behind is a reminder of its global impact. Smallpox was a deadly disease, with a mortality rate of about 30%. Thanks to a successful worldwide immunization program, the World Health Organization (WHO) declared smallpox eradicated in 1980, and routine vaccination ended. The last smallpox vaccine was administered in the US in the early 1980s.
The smallpox vaccine was delivered in a unique manner. It used a bifurcated (two-pronged) needle to make multiple punctures in the skin, delivering the virus to the dermis, just below the outer layer of the skin. This technique caused a controlled infection, stimulating the body's immune system to defend against the virus. The resulting bump developed into a blister, which scabbed over, leaving a permanent scar.
The scar, typically on the upper left arm, is a distinctive, round mark, slightly lower than the surrounding skin. It is a sign that the vaccine was successful and that the body mounted an immune response. The scar is less common nowadays, as smallpox vaccination is now limited to certain groups like military personnel and researchers.
The scar is a testament to the power of global collaboration and public health efforts. It is a reminder that immunization works and that we can eradicate diseases through collective action. The smallpox vaccine's success paved the way for other vaccines, like the Bacillus Calmette-Guérin (BCG) vaccine against tuberculosis, which also leaves a similar scar. These scars are a physical reminder of the importance of vaccination and the global achievements we can attain through medical advancements.
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Frequently asked questions
The vaccination mark on your arm is likely a smallpox vaccine scar, which was last administered in the US in the early 1970s and stopped being used worldwide in 1986. It could also be a Bacillus Calmette-Guerin (BCG) vaccine scar, which is used to protect against tuberculosis (TB).
The smallpox vaccine causes a minor, controlled infection in your skin, which your body fights off, leaving a small mark where the infection took place. The BCG vaccine also causes a blister to fill with pus, crust over, and form a scab, which can leave a scar.
The smallpox vaccine scar is typically round or oval-shaped, about the size of a dime, and may be lower than the surrounding skin. The BCG vaccine scar can look similar, but it is often depressed and can be treated with laser therapy.



































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