
Smallpox is a serious, contagious, and sometimes fatal disease caused by the variola virus. It was declared eradicated in 1980 following a successful worldwide vaccination program. The last naturally occurring case of smallpox was reported in 1977 in Africa. In the United States, routine vaccination against smallpox ended in 1972 due to the low risk of infection and the potential side effects of the vaccine. Today, smallpox vaccines are not recommended for the general public, but they are still being produced for research and to guard against potential bioterrorism threats.
| Characteristics | Values |
|---|---|
| Year routine vaccination against smallpox stopped in the US | 1972 |
| Reason routine vaccination was stopped | The risk of side effects from vaccination was worse than the risk of getting infected |
| Year smallpox was eradicated in the US | 1949 |
| Year smallpox was eradicated globally | 1980 |
| Year smallpox was eliminated globally | Late 1970s |
| Last naturally occurring case of smallpox | 1977 |
| First vaccine to be developed against a contagious disease | Smallpox vaccine |
| Year smallpox vaccination began in the US | 1800 |
Explore related products
What You'll Learn

Routine smallpox vaccination ended in 1972
Routine smallpox vaccination among the American public ended in 1972. This was due to the disease being eradicated in the United States, with the last case occurring in 1949. The World Health Organization (WHO) conducted a global vaccination campaign from 1958 to 1977, which successfully eradicated smallpox worldwide. Smallpox is a serious, contagious, and sometimes fatal disease caused by the variola virus.
The smallpox vaccine was first introduced in 1796 by British physician Edward Jenner, who demonstrated that infection with the mild cowpox virus conferred immunity against smallpox. The vaccine was transmitted from person to person through arm-to-arm vaccination until the end of the 19th century. During this time, there were no adequate methods for assessing vaccine safety, and contaminated vaccines occasionally transmitted infections such as tetanus and tuberculosis. In the 1840s, the vaccine was successfully maintained in cattle, and by the 1880s, calf lymph vaccine became the leading smallpox vaccine.
In the 1950s to 1970s, first-generation vaccines grown on the skin of live animals were widely distributed to eradicate smallpox. Second-generation vaccines, grown in cell cultures, were used in some areas during the smallpox eradication campaign. Routine smallpox vaccination played a crucial role in eliminating the disease as a public health threat. However, due to the success of these vaccination programs, routine smallpox vaccination is no longer necessary for the general public.
While smallpox has been eradicated, concerns remain about the potential use of the virus for bioterrorism. As a result, the United States government has implemented a smallpox preparedness program, which includes vaccinating healthcare and public health workers who would be first responders in the event of a bioterrorist attack. Additionally, there is an emergency supply of the smallpox vaccine that could be used to prevent the spread of the disease if necessary.
The smallpox vaccine is still being produced for research and to guard against potential biological threats. It is important to note that the smallpox vaccine is not given like a typical shot. Instead, it is administered using a bifurcated needle that pricks the skin multiple times, causing a sore spot and possibly some bleeding. While most people experience mild reactions, there are rare cases of more severe responses, emphasizing the need for careful consideration of contraindications and precautions before administering the vaccine.
Hep B Vaccine: Lifetime Immunity or Booster Needed?
You may want to see also
Explore related products

Smallpox was eradicated in the US in 1949
Smallpox is a serious, contagious, and sometimes fatal disease caused by the variola virus. It is spread from person to person by infected saliva droplets, close personal contact, airborne spread, or direct contact with the smallpox rash or scabs. The smallpox vaccine, the oldest vaccine in existence, has successfully eradicated the disease worldwide.
Smallpox vaccination in the United States began in 1800, but it wasn't until the 20th century that its routine widespread use occurred. The last case of smallpox in the United States was in 1949, and the disease was eradicated in the country by 1950. Globally, smallpox was eliminated as a naturally occurring threat to humans in the late 1970s, with the last naturally occurring case reported in Somalia in 1977.
Routine smallpox vaccination among the American public stopped in 1972 after the disease was no longer a threat. The risk of side effects from the vaccine was considered worse than the risk of infection. Today, smallpox vaccination is not recommended for the general public, as the disease has been eradicated. However, there are still two licensed smallpox vaccines in the United States, and an emergency supply is available should an outbreak occur.
The smallpox vaccine is unique in that it is not administered as a typical shot. Instead, it is given using a two-pronged needle that pricks the skin multiple times in a few seconds. This method causes a sore spot and some bleeding. A lesion or blister forms within the first week and eventually dries up and forms a scab in the second week. The scab falls off in the third week, leaving a small scar. While the vaccine is generally safe, it can cause mild side effects such as a sore arm, fever, and body aches.
The success of the smallpox vaccine is a testament to the power of vaccination campaigns and their ability to eradicate deadly diseases. With continued surveillance and containment efforts, the global community can remain vigilant against the re-emergence of smallpox and other eradicated diseases.
Chickenpox Vaccine: When Did It First Become Available?
You may want to see also
Explore related products
$17.9 $17.95

The last global case was in 1977
The last global case of smallpox was in 1977, in Somalia. This was less than a year after the original 10-year target date set by the World Health Organization (WHO) for the eradication of the disease.
Smallpox was eliminated from 20 countries in western and central Africa by 1970, and from Brazil in 1971. Indonesia followed in 1972, and by 1975, smallpox had been eradicated from the entire continent of Asia. Ethiopia stopped transmission in 1976, and finally, the last case was recorded in Somalia in 1977.
The World Health Assembly, acting on the recommendation of a WHO Global Commission, announced in May 1980 that worldwide eradication had been achieved. This came after a successful global vaccination campaign by the WHO from 1958 to 1977. The campaign emphasized two critical principles: ensuring that all vaccines met accepted standards and achieving satisfactory vaccination coverage.
Routine vaccination against smallpox in the United States ended in 1972 due to the risk of side effects outweighing the risk of infection. Smallpox was declared eradicated in the country in 1949.
Today, smallpox vaccines are not recommended for the general public, as the disease has been eradicated. However, there are still concerns about the potential use of the smallpox virus for bioterrorism. An emergency supply of the vaccine is available and could be used to prevent the spread of smallpox if released into the environment.
Vaccine Refusal: Options for Employers and Employees
You may want to see also
Explore related products

Smallpox vaccines are not recommended for the general public
Smallpox is a serious infectious disease caused by the variola virus. It has been responsible for the deaths of countless millions worldwide. However, vaccination led to the eradication of smallpox, with the last case seen in 1977. Routine smallpox vaccination among the American public stopped in 1972 after the disease was eradicated in the United States.
Smallpox vaccines are not currently recommended for the general public because the disease has been eradicated, and the virus no longer exists in nature. There are two licensed smallpox vaccines in the United States, and one investigational vaccine that may be used in a smallpox emergency. The smallpox vaccine is made from a virus called vaccinia, which is a poxvirus similar to smallpox, but less harmful. The smallpox vaccine contains a live vaccinia virus, not a killed or weakened virus like many other vaccines.
The Advisory Committee on Immunization Practices (ACIP) advises against non-emergency use of the smallpox vaccine in children younger than 18 years of age and in geriatric populations (generally, those aged 65 and above). The ACIP also recommends that people who are using steroid eye drops should wait until they are no longer using the medication before getting the vaccine. In addition, careful monitoring of smallpox vaccinations has suggested that the vaccine may cause side effects on the heart, such as heart pain (angina), heart inflammation (myocarditis), and inflammation of the membrane covering the heart lining (pericarditis).
In the event of a smallpox outbreak, there is enough smallpox vaccine to vaccinate everyone who would need it. The smallpox vaccine can protect people from getting sick or make the disease less severe if they receive the vaccine either before or within a week of coming into contact with the smallpox virus. The best way to prevent smallpox is through vaccination. If given to a person before exposure to smallpox, the vaccine can completely protect them.
Vaccine Route and Site: What's the Right Combo?
You may want to see also
Explore related products

Smallpox vaccination began in the US in 1800
Smallpox is a disease caused by the variola virus, which has been eradicated due to a successful worldwide vaccination programme. The last naturally occurring case of smallpox was reported in 1977 in Africa, and the World Health Organization (WHO) declared smallpox eliminated worldwide in 1980.
Jenner discovered that an infection with the relatively mild cowpox virus conferred immunity against the deadly smallpox virus. In 1796, he demonstrated the world's first vaccine, using the same principle as variolation but with a less dangerous viral source. He inoculated 8-year-old James Phipps with matter from a cowpox sore and later with smallpox, and Phipps developed resistance to the disease.
Until the 1880s, the smallpox vaccine was transmitted from one person to another through arm-to-arm vaccination. During this period, there were no methods to assess the safety of the vaccine, and contaminated vaccines sometimes transmitted infections. In the 1840s, smallpox vaccination became mandatory in Britain and parts of the US, and certificates were required for travel.
Routine smallpox vaccination among the American public stopped in 1972 after the disease was eradicated in the United States, and it is no longer routinely performed on the general public. However, smallpox vaccines are still produced for research and to guard against potential outbreaks.
Cold Storage: mRNA Vaccine Efficacy Preserved
You may want to see also
Frequently asked questions
Routine smallpox vaccination among the American public stopped in 1972 after the disease was eradicated in the United States.
The risk of side effects from vaccination was worse than the risk of getting infected.
Yes, smallpox was declared globally eradicated in 1980 following worldwide vaccination programs.
Yes, smallpox vaccines are still being produced for research and to guard against bioterrorism, biological warfare, and mpox. There are two licensed smallpox vaccines in the United States.




























