
Chickenpox, also known as the varicella-zoster virus, is a highly contagious disease that causes an itchy rash with fluid-filled blisters. While chickenpox is usually mild, it can sometimes be severe and even life-threatening. The risk of severe illness is higher in infants, older adults, and immunocompromised individuals. Vaccination is an effective way to protect against chickenpox and prevent serious complications. The chickenpox vaccine, also known as the varicella vaccine, is a live vaccine that contains a weakened version of the varicella-zoster virus. Two types of chickenpox vaccines are available: ProQuad® (MMRV), which combines the measles, mumps, rubella, and varicella vaccines, and Varivax®, which contains only the varicella vaccine. Both vaccines are safe and effective, providing long-lasting immunity against chickenpox.
| Characteristics | Values |
|---|---|
| Name | Varicella vaccine, also known as the chickenpox vaccine |
| Virus | Varicella-zoster virus |
| Type | Live vaccine |
| Effectiveness | 70% to 90% effective for preventing varicella and more than 95% effective for preventing severe varicella |
| Dosage | 2 doses |
| Administration | Injection just under the skin |
| Side effects | Mild and rare |
| Age | Licensed for use in people 12 months or older |
| Availability | First became commercially available in 1984 |
What You'll Learn
- The chickenpox vaccine is also known as the varicella vaccine
- Two vaccines are licensed for use in the US
- The chickenpox vaccine is recommended for babies and adults without immunity
- The vaccine contains a weakened version of the varicella-zoster virus
- Side effects are rare but can include mild symptoms

The chickenpox vaccine is also known as the varicella vaccine
The varicella vaccine is highly effective in preventing chickenpox. One dose of the vaccine prevents 95% of moderate cases and 100% of severe cases. Two doses are even more effective and offer lifelong protection for most people. Studies have shown that vaccinated individuals had antibodies for at least 10 to 20 years after vaccination. The vaccine not only protects the individual but also helps protect others in the community, including those who are at high risk or unable to get vaccinated.
There are two types of chickenpox vaccines available: ProQuad® and Varivax®. ProQuad® is a combination vaccine that includes measles, mumps, rubella, and varicella (MMRV). It is approved for children ages 12 months to 12 years old. Varivax® is a single-antigen varicella vaccine and is safe for anyone 12 months or older. The CDC recommends two doses of the vaccine, given subcutaneously and separated by at least three months.
While side effects from the varicella vaccine are rare, they can occur and are typically mild and self-limiting. However, in rare cases, more serious reactions such as pneumonia, infection of the brain or spinal cord, and seizures can occur. Individuals with compromised immune systems should be cautious as there is a risk of infection associated with live vaccines. It is important to consult with a healthcare provider to determine the best course of action and to discuss any concerns or potential side effects.
The varicella vaccine has significantly reduced the number of chickenpox cases, hospitalizations, and deaths, especially in children. It is recommended for babies, older children, adolescents, and adults who have never had chickenpox or received the vaccine. The vaccine not only prevents severe illness but also reduces the risk of shingles (herpes zoster) in older adults. Overall, the chickenpox or varicella vaccine is a safe and effective way to protect against chickenpox and its potential complications.
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Two vaccines are licensed for use in the US
Chickenpox, also known as the varicella-zoster virus, is a highly contagious disease that causes an itchy rash with fluid-filled blisters. It is usually mild, but it can be severe and even life-threatening in some cases. The risk of chickenpox is highest in infants, older adults, and immunocompromised people.
Two vaccines containing the varicella virus are licensed for use in the United States: Varivax® and ProQuad®. Varivax® is a single-antigen varicella vaccine, while ProQuad® is a combination measles, mumps, rubella, and varicella (MMRV) vaccine. Both vaccines are derived from the Oka strain and contain a live, attenuated varicella-zoster virus. The Oka strain was first developed in the early 1970s in Japan, and an American vaccinologist, Maurice Hilleman, later developed a chickenpox vaccine based on this strain in 1981. Varivax® was licensed for use in the US by Merck in 1995 and is recommended for anyone 12 months and older. ProQuad® is approved for healthy children between 12 months and 12 years old.
The chickenpox vaccine is recommended for babies and adults who have never been vaccinated or had chickenpox. Two doses of the vaccine are recommended for optimal protection, and they should be given subcutaneously, separated by at least three months. The vaccine is safe and effective, providing long-lasting immunity. Studies have shown that the vaccine is 97% effective in the first year and remains stable at 81-86% effective from the second to the eighth year. Most vaccinated individuals who still develop chickenpox experience a milder form of the disease.
In addition to the two licensed vaccines, separate injections of MMR and varicella vaccines may be given to children 12 months to 12 years old, with a preference for MMRV vaccine at certain ages. The CDC recommends that for the first dose, parents or caregivers express their preference for separate injections or MMRV. The long-term duration of protection from the varicella vaccine is unknown, but some individuals vaccinated over twenty years ago still show no signs of waning immunity. However, others have become vulnerable within six to eight years.
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The chickenpox vaccine is recommended for babies and adults without immunity
Chickenpox, also known as the varicella-zoster virus, is a highly contagious disease that causes an itchy rash with fluid-filled blisters. It can also lead to a fever, loss of appetite, and headaches. While chickenpox is typically mild, it can become severe and even life-threatening, especially in infants, older adults, and immunocompromised people.
The chickenpox vaccine, also known as the varicella vaccine, is a live vaccine that contains a weakened version of the varicella-zoster virus. It is given as a two-dose series of shots, with the first dose administered at 12 to 15 months and the second dose at 4 to 6 years. For adolescents and adults, the two doses should be administered at least 28 days apart.
The vaccine is recommended for babies and adults without immunity to chickenpox. Immunity can be determined through a blood test that checks for antibodies. Those without immunity are at risk of developing chickenpox if exposed to the virus. Vaccination within three to five days of exposure can help prevent infection or reduce its severity.
The chickenpox vaccine is highly effective in preventing the disease. One dose of the vaccine prevents 95% of moderate cases and 100% of severe cases. Two doses are even more effective, providing lifelong protection for most people. Vaccinated individuals who do develop chickenpox typically experience milder symptoms, such as a reduced number of blisters and lower fever.
In addition to protecting the individual, the chickenpox vaccine also helps protect others in the community, including those who cannot get vaccinated. Vaccinating a large portion of the population contributes to herd immunity, reducing the overall spread of the disease.
It is important to note that side effects from the chickenpox vaccine are typically mild and rare, and severe reactions are uncommon. However, individuals with compromised immune systems should consult with their healthcare provider before receiving the vaccine, as there is a risk of infection associated with live vaccines.
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The vaccine contains a weakened version of the varicella-zoster virus
The chickenpox vaccine, also known as the varicella vaccine, is an immunization that protects children and adults from the varicella-zoster virus, which causes chickenpox. Chickenpox is a highly contagious disease characterised by an itchy rash with fluid-filled blisters, fever, loss of appetite, and headaches. Although it is usually mild, chickenpox can sometimes be severe and even life-threatening, especially in infants, older adults, and immunocompromised people.
The varicella vaccine contains a weakened version of the varicella-zoster virus. This type of vaccine is known as a live vaccine, and it works by causing the body to produce its own antibodies against the virus. Live vaccines generally provide long-lasting immunity. Studies have shown that people vaccinated against varicella had antibodies for at least 10 to 20 years after vaccination. A case-control study found that one dose of the varicella vaccine was 97% effective in the first year after vaccination and 86% effective in the second year. From the second to the eighth year after vaccination, the vaccine effectiveness remained stable at 81% to 86%.
The varicella vaccine was developed by Michiaki Takahashi and colleagues in Japan in the early 1970s and first became commercially available in 1984. It was licensed for use in the US by Merck in 1995 under the brand name Varivax. Varivax is a single-antigen varicella vaccine and is safe for anyone 12 months and older. Another vaccine, ProQuad, is a combination measles, mumps, rubella, and varicella (MMRV) vaccine and is approved for healthy children between 12 months and 12 years old. Both vaccines contain live, attenuated varicella-zoster viruses derived from the Oka strain.
While side effects from the chickenpox vaccine are rare, they can occur and are typically mild and self-resolving. However, in rare cases, more serious reactions such as pneumonia, infection of the brain or spinal cord, and seizures can occur. People with serious immune system problems should not receive the varicella vaccine as it may cause a life-threatening infection. Additionally, those who are pregnant or may be pregnant should not receive the vaccine. It is important to consult with a healthcare provider to determine the best course of action regarding the chickenpox vaccine.
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Side effects are rare but can include mild symptoms
The chickenpox vaccine, also known as the varicella vaccine, is an immunization that protects children and adults from the varicella-zoster virus, which causes chickenpox. The two types of vaccines that are licensed for use in the United States are Varivax®, the single-antigen varicella vaccine, and ProQuad®, a combination measles, mumps, rubella, and varicella (MMRV) vaccine. Both vaccines contain live, attenuated varicella-zoster viruses derived from the Oka strain.
Side effects from the chickenpox vaccine are rare but can include mild symptoms such as a rash, mild chickenpox, and breakthrough disease. In some cases, vaccinated individuals may develop shingles (herpes zoster) years later, although this is much less common than after the chickenpox disease. It is also possible to faint after receiving the vaccine, as is the case with other medical procedures.
More serious reactions are very rare but may include pneumonia, infection of the brain or spinal cord covering, or seizures associated with fever. People with serious immune system problems should not receive the varicella vaccine as it may cause a life-threatening infection. Additionally, pregnant women should not get the varicella vaccine, and those who are trying to conceive should consult their healthcare provider.
Allergic reactions to the vaccine are possible and may include hives, swelling of the face and throat, difficulty breathing, a fast heartbeat, dizziness, or weakness. If any of these symptoms occur, immediate medical attention is required. It is important to report adverse reactions to the Vaccine Adverse Event Reporting System (VAERS).
It is recommended to consult with a healthcare provider to discuss any concerns or potential risks associated with the chickenpox vaccine.
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Frequently asked questions
The chickenpox vaccine is also known as the varicella vaccine.
The FDA has approved two types of chickenpox vaccines: ProQuad® and Varivax®. ProQuad® contains varicella along with the measles, mumps and rubella vaccine (MMRV), and is given to children aged 12 months to 12 years old. Varivax® contains only varicella and is safe for anyone 12 months and older.
Two doses of the chickenpox vaccine are recommended for children as the best way to protect against chickenpox. The doses should be given subcutaneously and separated by at least three months.
The chickenpox vaccine is recommended for babies and adults who have never had the vaccine or chickenpox. It is also recommended for older children, adolescents, and adults who are not already immune to chickenpox.

