
Hepatitis A is a highly contagious liver infection caused by the hepatitis A virus (HAV). It is primarily transmitted via the faecal-oral route, through consumption of contaminated food and water, or by coming into direct contact with an infected person. The hepatitis A vaccine is an inactivated vaccine, which means it contains a killed version of the hepatitis A virus. It is safe and highly effective in preventing HAV infection, offering almost 100% protection. While the exact duration of protection is unknown, research suggests that the vaccine may offer long-term protection, with some studies indicating possible immunity for up to 20-40 years or even lifetime protection. The hepatitis A vaccine is recommended for children and adults, especially those at increased risk of infection, such as international travellers and those with certain medical or lifestyle risk factors.
| Characteristics | Values |
|---|---|
| Longevity of protection | It is unclear exactly how long the hepatitis A vaccine works, but it does provide long-term protection. Research suggests protection may last at least 20 years, with some sources claiming it could be up to 30-40 years or even lifetime protection. |
| Dosage | Two doses are required for children and adults, with the second dose administered 6-18 months after the first dose. |
| Availability | The hepatitis A vaccine is available in the United States under the brand names Havrix and Vaqta. A combination vaccine for hepatitis A and B, called Twinrix, is also available. |
| Safety | Hepatitis A vaccines are safe and highly effective in preventing HAV infection. |
| Recommendations | The CDC recommends hepatitis A vaccination for children ages 12-23 months and unvaccinated adults who are at increased risk of infection or severe disease. The vaccine is also recommended for international travelers and those with certain occupational or lifestyle risks. |
| Contraindications | The vaccine is not suitable for people who have had a severe allergic reaction to the hepatitis A vaccine or any of its components. People who are moderately or severely ill should wait until they recover before getting the vaccine. |
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What You'll Learn

Hepatitis A vaccine may offer lifetime protection
Hepatitis A is a disease that causes liver inflammation and, if left untreated, can lead to chronic liver inflammation, liver failure, liver cirrhosis, and liver cancer. The virus can be contracted through contact with contaminated food, drinks, or objects. The hepatitis A vaccine is highly effective in preventing the hepatitis A virus (HAV) infection and is generally recommended for children and adults who are at increased risk of infection.
The hepatitis A vaccine is an inactivated vaccine, meaning it contains a killed version of the hepatitis A virus. It is safe and offers almost 100% protection against the disease. While the exact duration of protection is unknown, research suggests that the vaccine may offer long-term protection, with some studies indicating protection lasting at least 20 years. The Immunize.org suggests that the vaccine might offer protection for at least 25 years for adults and about 14-20 years for children. A 2020 review of research even states that the vaccine may provide lifetime protection.
The vaccine schedule for hepatitis A varies depending on the brand of the vaccine, Havrix or Vaqta, and the age of the recipient. Children can receive their first vaccine at 12 months old or older, with the second dose administered 6-12 months later for Havrix and 6-18 months later for Vaqta. Adults also require two doses, with the second dose administered 6-12 months after the first dose. For those travelling to areas with a risk of hepatitis A, an accelerated schedule of three doses over 30 days, followed by a booster dose at 12 months, can be administered.
While the hepatitis A vaccine is highly effective, it is not suitable for everyone. Individuals with a history of severe allergic reactions to the vaccine or its components should not receive the vaccine. Additionally, those who are moderately or severely ill should wait until they recover before getting vaccinated. However, it is safe to administer the vaccine to individuals with minor illnesses, such as a cold.
Overall, the hepatitis A vaccine is a safe and effective way to prevent HAV infection and may offer long-term protection, with some evidence suggesting lifetime protection. It is important to follow the recommended vaccine schedule to ensure optimal protection against the disease.
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Two doses of the vaccine may protect for 30-40 years
While it is unclear exactly how long the hepatitis A vaccine works, it does provide long-term protection. Research suggests that protection against hepatitis A may last at least 20 years in people who receive the full vaccine series. Immunize.org suggests that the hepatitis A vaccine might offer protection for at least 25 years for adults and about 14–20 years for children.
Two doses of the hepatitis A vaccine may protect for 30–40 years or even provide lifetime protection. The vaccine is highly effective in preventing HAV infection, and the immunoglobulin G (IgG) anti-HAV produced after vaccination confers long-term immunity. The hepatitis A vaccine is an inactivated vaccine, meaning it contains the killed version of the hepatitis A virus.
The hepatitis A vaccine is recommended for specific groups considered at higher risk of infection. These include indigenous children, people with medical risk factors, those with developmental disabilities, and travellers to regions with intermediate to high hepatitis A endemicity. In the United States, the vaccine is routinely given to children as part of their childhood vaccinations. The Advisory Committee on Immunization Practices (ACIP) recommends vaccination for children aged 12–23 months and catch-up vaccination for children aged 2–18 years who have not previously been vaccinated.
Hepatitis A is a highly contagious liver infection caused by the hepatitis A virus (HAV). It can be contracted through contact with contaminated food, drinks, or objects. The infection first attaches itself to the intestines before gradually spreading to the liver, leading to inflammation. Proper hygiene, careful food handling, and safe water consumption are crucial in preventing hepatitis A infection. Vaccination is the safest and most effective way to ensure protection against the disease.
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Vaccination is recommended for children and adults at risk
Vaccination is recommended for children from the age of 1, with the first dose administered at 12-23 months old and the second dose at 2-4 years old. In some countries, the vaccine is included in the routine immunisation schedule for children at increased risk of infection. This includes Indigenous children in certain states in Australia, where the hepatitis A vaccine is administered at 18 months of age and again at 4 years old.
The Advisory Committee on Immunization Practices (ACIP) recommends routine vaccination for children aged 12-23 months and catch-up vaccination for children aged 2-18 years who have not previously received the vaccine. ACIP also recommends hepatitis A vaccination for unvaccinated adults who are at increased risk of infection or severe disease from infection. This includes people with medical risk factors, such as chronic liver disease or HIV, and those with occupational or lifestyle risks, such as international travel to endemic areas, men who have sex with men, and people who use or inject drugs.
Pregnant women may also require the vaccine if they are at risk of infection or severe disease from hepatitis A. However, the decision to vaccinate pregnant or breastfeeding women should be made in consultation with a medical practitioner, considering the risks and benefits.
It is important to note that the hepatitis A vaccine is not suitable for everyone. Individuals with a history of severe allergic reactions to the vaccine or its components should avoid vaccination. Additionally, people who are moderately or severely ill should wait until they recover before receiving the vaccine.
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The vaccine is safe and highly effective
Hepatitis A vaccines are safe and highly effective in preventing HAV infection. The immunoglobulin G (IgG) anti-HAV produced after vaccination confers long-term immunity. Scientific evidence overwhelmingly supports the safety of hepatitis A vaccines. Randomised controlled trials show that the vaccines have protective efficacy of nearly 100%.
The hepatitis A vaccine is an inactivated vaccine, meaning it contains a killed version of the hepatitis A virus. It is administered in two doses for children and adults, with the second dose taking place 6-18 months after the first dose. The vaccine is generally safe for people with minor illnesses, such as a cold, but those who are moderately or severely ill should wait until they recover before getting the vaccine.
The Advisory Committee on Immunization Practices (ACIP) recommends routine vaccination for children ages 12-23 months and catch-up vaccination for children ages 2-18 years who have not previously received the vaccine. ACIP also recommends hepatitis A vaccination for unvaccinated adults who are at increased risk of infection or severe disease from infection. The CDC further recommends vaccination for international travellers, men who have sex with men, and people who use or inject drugs.
The hepatitis A vaccine is not routinely recommended in countries like Australia, except for Indigenous children in some states and people with medical and lifestyle risk factors. However, travel health professionals recommend the vaccine for all travellers going abroad, regardless of destination, due to the possibility of contracting the infection from imported foods.
Overall, the hepatitis A vaccine is safe and highly effective, providing long-term protection against the hepatitis A virus.
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It is recommended for travellers to high-risk regions
Hepatitis A is a liver infection that can be contracted through contaminated food, drinks, or objects. It is a highly contagious virus that can lead to severe illness, including liver failure and, in some cases, loss of life if not treated properly. The exact duration of protection offered by the hepatitis A vaccine is unknown, but it is thought to provide long-term protection, possibly for a lifetime.
The hepatitis A vaccine is recommended for travellers to high-risk regions, such as parts of Africa, Asia, Central America, and South America. This is because the risk of contracting the virus is higher in areas with poor sanitation and unsafe water sources. Travellers to these regions are advised to receive the vaccine before their trip to reduce the risk of infection. It is important to get vaccinated at least one month before travelling to ensure the vaccine has time to take effect.
In addition to travellers, the hepatitis A vaccine is also recommended for people who are at increased risk of infection or severe disease. This includes unvaccinated adults and children, people with medical risk factors, those with developmental disabilities, and those with occupational risks, such as healthcare workers and chefs.
The hepatitis A vaccine is generally safe and well-tolerated. However, it is important to note that people who are ill should wait until they recover before getting the vaccine. Additionally, those with a history of severe allergic reactions to any component of the vaccine should not receive it.
The vaccine is typically given in two doses for children and adults, with the second dose administered 6-18 months after the first dose. For travellers, an accelerated schedule may be administered, with three doses given over 30 days, followed by a booster dose at 12 months. This provides long-term protection and is a safe and effective way to prevent hepatitis A infection.
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Frequently asked questions
The hepatitis A vaccine is recommended for specific groups of people who are considered at a higher risk of infection. This includes indigenous children, people with medical risk factors, those with developmental disabilities, and travellers to regions with intermediate to high hepatitis A endemicity. In the US, the Department of Health and Human Services (HHS) recommends that every child receives the hepatitis A vaccine. The CDC also recommends that international travellers, men who have sex with men, and people who use or inject drugs get vaccinated.
It is unclear exactly how long the hepatitis A vaccine provides protection, but it does offer long-term protection and may even offer lifelong immunity. Research suggests that protection against hepatitis A may last at least 20 years, with some studies suggesting it could be up to 30-40 years or even lifetime protection.
The hepatitis A vaccine is typically administered in two doses for children and adults. The first dose should be given at 12-23 months old, and the second dose at 2-4 years old. The second dose should be administered 6-18 months after the first dose, depending on the vaccine brand.
The hepatitis A vaccine is safe and highly effective, with the most frequently reported side effects being fever, injection site reactions, and rash. People who are moderately or severely ill should wait until they recover before getting the vaccine. It should not be administered to those with a history of severe allergic reaction to the vaccine or its components, including yeast or neomycin.








































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