
The hepatitis B vaccine is recommended for all infants at birth, children up to 18 years of age, and adults at high risk of contracting the hepatitis B virus. The vaccine is given as a series of two or three shots, depending on the brand, and has been proven safe for pregnant women. It is created in yeast cells, and no one has been shown to be allergic to the yeast proteins it contains. The hepatitis B vaccine is considered one of the safest and most effective vaccines ever made, with over one billion doses administered worldwide. It does not contain the hepatitis B virus.
| Characteristics | Values |
|---|---|
| Who should get the hepatitis B vaccine? | All infants, children and adolescents younger than 19, adults 19-59, adults 60 and older with risk factors for hepatitis B, pregnant women, people with hemophilia, people with chronic liver disease, sexually active people who are not in long-term, mutually monogamous relationships, people with end-stage renal disease, residents and staff of facilities for people with developmental disabilities, travellers to countries where hepatitis B is common, military personnel, males who have sex with males, people who use illegal injection drugs, laboratory workers who handle hepatitis A and B viruses, police, people who give first aid or medical help, workers who come in contact with stool or sewage |
| How many doses of the hepatitis B vaccine are required? | 2 or 3 shots depending on the vaccine brand. If you get the three-shot series, the shots will be given over a 6-month period. If you get the two-dose vaccine, you will get them about one month apart. |
| How safe is the hepatitis B vaccine? | The hepatitis B vaccine is considered one of the safest and most effective vaccines ever made. No evidence has been found that the vaccine causes sudden infant deaths (SIDs), autism, multiple sclerosis, or other neurological disorders. Common side effects may include soreness, swelling and redness at the injection site. About 1 out of every 600,000 doses will cause a severe allergic reaction called anaphylaxis. |
| Who should not get the hepatitis B vaccine? | People who have had a serious allergic reaction (anaphylaxis) to a previous dose of the vaccine or an ingredient in the vaccine. |
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What You'll Learn

Hepatitis B vaccine safety
Hepatitis B is a liver infection caused by the hepatitis B virus (HBV). It is spread by contact with body fluids, including blood, saliva, semen, and vaginal fluids, as well as by needle sticks, sharing needles, and from mother to child. The World Health Organization (WHO) estimates that there were over 5.5 million cases of acute hepatitis B infection and over 520,000 deaths from hepatitis B-related diseases in 2000.
The hepatitis B vaccine has been available since the 1980s, and over 1 billion doses have been administered worldwide. It is considered one of the safest and most effective vaccines ever made. The vaccine is composed of highly purified preparations of the hepatitis B surface antigen (HBsAg), which is a glycoprotein found on the envelope of the hepatitis B virus. The vaccine does not contain the hepatitis B virus itself.
The World Health Organization (WHO), the U.S. Centers for Disease Control and Prevention (CDC), and many medical societies have conducted numerous studies on the safety of the hepatitis B vaccine. These studies have concluded that the vaccine does not cause sudden infant death syndrome (SIDS), autism, multiple sclerosis, or other neurological disorders. The CDC has also reviewed reports of adverse events following hepatitis B vaccination and found no new or unexpected safety concerns.
While the hepatitis B vaccine is generally safe, it can have side effects like any other medicine. The most common side effects include injection site pain, soreness, redness, headache, and fatigue, and are usually mild and last 1-2 days. In rare cases, more serious adverse events have been reported, such as fever, vomiting, and injection site redness, especially when the hepatitis B vaccine is given in combination with other vaccines. However, these side effects are typically not life-threatening and are consistent with pre-licensure clinical trials and post-licensure monitoring and research.
The hepatitis B vaccine is recommended for all newborns, infants, children up to 18 years of age, adults at high risk of infection, adults 19-59 years of age, and older adults with risk factors for hepatitis B. The CDC and FDA are committed to ongoing monitoring of vaccine safety and encourage reporting any adverse events following vaccination.
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Who should get the hepatitis B vaccine?
The hepatitis B vaccine is recommended for all infants at birth, children up to the age of 18, and adults at high risk of contracting the virus. The World Health Organization (WHO) and the U.S. Centers for Disease Control and Prevention (CDC) recommend the hepatitis B vaccine for newborns and children up to 18 years old. The CDC further recommends the vaccine for adults aged 19 to 59 and those 60 and older with risk factors.
The hepatitis B vaccine is safe for pregnant women and can be administered concurrently with other vaccines to children and adults. It is typically given in two or three doses, depending on the brand, with the shots spaced about a month apart.
Certain groups are more likely to be exposed to the hepatitis B virus, including:
- Infants born to mothers with hepatitis B
- Sexually active individuals who are not in a long-term, monogamous relationship
- People seeking treatment for sexually transmitted infections
- People with end-stage renal disease or chronic liver disease
- Residents and staff of facilities for people with developmental disabilities
- International travellers to countries where hepatitis B is common
- Military personnel
- Laboratory workers and healthcare professionals who handle blood or body fluids
The hepatitis B vaccine is considered one of the safest and most effective vaccines ever made, with over 1 billion doses administered worldwide. It is the first "anti-cancer" vaccine as it prevents hepatitis B, the leading cause of liver cancer.
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How many doses of the hepatitis B vaccine are required?
The number of doses of the hepatitis B vaccine required depends on the age of the recipient and the brand of the vaccine. The World Health Organization (WHO) recommends that all infants receive the first dose of the hepatitis B vaccine within 24 hours of birth. This is often referred to as the "birth dose". Two additional shots are then administered at one month and six months of age.
For children up to 18 years of age, the hepatitis B vaccine is recommended. People aged 19 years and younger should receive three doses of the vaccine. The same applies to people aged 20 and older. However, adults on dialysis or predialysis should receive three doses of the dialysis formulation, while adults on haemodialysis should receive four doses.
The hepatitis B vaccine is also available as a two-dose vaccine, with shots administered about one month apart. This is approved for use in adults aged 18 and older.
The hepatitis B vaccine is considered one of the safest and most effective vaccines ever made, with more than 1 billion doses administered worldwide.
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Hepatitis B vaccine side effects
The hepatitis B vaccine is a safe and effective vaccine that prevents infection by the hepatitis B virus. It works by causing the body to produce its own antibodies against the disease. The vaccine is made without any human blood or blood products, and it cannot give you the hepatitis B virus or the human immunodeficiency virus (HIV). It is recommended for all newborns, infants, children, adolescents, and adults at high risk.
While the hepatitis B vaccine is generally safe, some people may experience mild side effects. Soreness at the injection site is the most common side effect. Other possible side effects include fever, local reactions at the injection site, and skin rash. These side effects are usually not serious and often do not require medical attention. However, it is important to consult a healthcare professional if any side effects persist or are bothersome.
In rare cases, more severe side effects may occur. One study reported a rate of 17.55 adverse events per 100,000 doses of the hepatitis B vaccine. Most of these events were non-serious, and the vaccine has been shown to be safe for pregnant women and breastfeeding mothers. However, it is always important to discuss the potential risks and benefits of any vaccine with a healthcare professional before getting vaccinated.
The hepatitis B vaccine does not contain the live hepatitis B virus. Instead, it contains one of the viral envelope proteins, the Hepatitis B surface antigen (HBsAg). This protein is produced by yeast cells and triggers the production of antibodies against HBsAg in the bloodstream. These antibodies then provide immunity against HBV infection.
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Hepatitis B vaccine effectiveness
Hepatitis B is a serious disease that affects the liver and can cause death. It is caused by the hepatitis B virus (HBV) and is spread by contact with body fluids, such as blood, saliva, semen, or vaginal fluids; by needle sticks or sharing needles; or from mother to child. The World Health Organization (WHO) recommends that all newborns receive the hepatitis B vaccine as soon as possible after birth, preferably within 24 hours. This birth dose can effectively prevent mother-to-child transmission and is a core strategy for the prevention of hepatitis B infection.
The hepatitis B vaccine is a series of two or three shots, depending on the vaccine brand. The complete vaccine series induces immunity in more than 95% of infants, children, and young adults. Protection lasts at least 20 years and is possibly lifelong. The vaccine works by causing the body to produce its own protection (antibodies) against the disease. It is considered one of the safest and most effective vaccines ever made, with over one billion doses given worldwide.
In addition to newborns, the following groups are recommended to receive the hepatitis B vaccine if they have not already: children up to age 18, adults 19-59, and adults 60 and older with risk factors for hepatitis B. High-risk groups include people who frequently require blood or blood products, dialysis patients, recipients of solid organ transplants, healthcare workers, and travellers to endemic areas.
The hepatitis B vaccine is generally safe and effective, but some common side effects may include soreness, swelling, and redness at the injection site. It is important to note that the vaccine series will not benefit those who currently have an HBV infection or have recovered from a past infection. However, it can provide lifetime protection for those without hepatitis B who get vaccinated as soon as possible.
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Frequently asked questions
No, the hepatitis B vaccine does not contain the hepatitis B virus. The vaccine works by causing your body to produce its own protection (antibodies) against the disease.
The hepatitis B vaccine is recommended for all infants at birth, children up to 18 years of age, and adults at high risk of infection. The World Health Organization (WHO) and the U.S. Centers for Disease Control and Prevention (CDC) also recommend the vaccine for adults 19-59 years of age and adults 60 and older who are at high risk.
The number of doses depends on the vaccine brand and can vary from two to three shots. Infants are typically given three doses, with the first dose administered within 24 hours of birth, the second dose one to two months later, and the third dose between six and 18 months of age.
Yes, the hepatitis B vaccine is considered one of the safest and most effective vaccines ever made. Numerous studies have been conducted by organizations such as the World Health Organization and the U.S. Centers for Disease Control and Prevention, and no evidence has been found linking the vaccine to sudden infant death syndrome (SIDS), autism, multiple sclerosis, or other neurological disorders. Common side effects may include soreness, swelling, and redness at the injection site.
Yes, the hepatitis B vaccine is safe for pregnant women. However, it is important to consult with a doctor to determine the best option for each individual case.











































