
Hepatitis B is a liver disease caused by the hepatitis B virus (HBV). The hepatitis B vaccine is a safe and effective way to prevent infection and is recommended for people of all ages. The World Health Organization (WHO) recommends that all newborns receive the first dose of the hepatitis B vaccine within 24 hours of birth. The vaccine is also recommended for children up to the age of 18 and for adults, especially those at high risk of infection. The vaccine is typically given in a series of two or three shots, depending on the brand, with doses administered one month apart. It is important to complete all doses of the vaccine to ensure full protection.
| Characteristics | Values |
|---|---|
| Vaccine name | Hepatitis B vaccine |
| Vaccine type | Injection |
| Number of doses | 2 or 3 |
| Dosage interval | 1 month apart |
| Total time | 6 months |
| Recommended for | Newborns, children, adolescents, adults |
| Protection | Hepatitis B, hepatitis delta, liver cancer |
| Protection duration | Lifetime |
| Side effects | Soreness at the injection site |
| Availability | Doctor's office, local health department or clinic |
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What You'll Learn

Hepatitis B vaccine schedules
The hepatitis B vaccine is generally administered as an injection in the arm. The vaccine is safe and effective, and most people do not experience any side effects. The vaccination schedule varies depending on age, brand, and country. Here is a detailed breakdown of the hepatitis B vaccine schedules:
Newborns and Infants
The World Health Organization (WHO) recommends that all newborns receive the first dose of the hepatitis B vaccine within 24 hours of birth, often referred to as the "birth dose." The subsequent shots are typically given at 1 month and 6 months of age. It is essential to start the hepatitis B vaccine series at birth to ensure protection against hepatitis B for life.
Children and Adolescents
The hepatitis B vaccine is recommended for children and adolescents younger than 19 who have not been vaccinated. The vaccination schedule for this age group may vary, but it typically involves a series of two or three shots, depending on the vaccine brand. The Advisory Committee on Immunization Practices (ACIP) recommends that unvaccinated children younger than 18 years of age complete a 2-dose series with a minimum interval of 6 months between doses.
Adults
Hepatitis B vaccination is recommended for adults aged 19-59 and older individuals with risk factors for hepatitis B. The vaccination schedule for adults can vary depending on the brand and individual factors. The Heplisav-B vaccine, approved for adults aged 18 and older, is administered as two doses given one month apart. For adults who require three doses, the shots are typically given over a 6-month period.
It is important to note that alternative schedules may be considered, but a third or fourth booster dose is generally needed for maximum long-term protection. Additionally, in some cases, such as short-notice travel, an accelerated vaccination schedule might be recommended.
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Hepatitis B vaccine safety
Hepatitis B is a liver infection caused by the hepatitis B virus (HBV). It can range from a mild, short-term, acute illness lasting a few weeks to a serious, long-term, chronic infection. The best way to prevent hepatitis B is by getting vaccinated. The hepatitis B vaccine is safe and effective, and it gives long-term protection against illness from acute and chronic infection. It is safe for pregnant women and can also be administered to infants.
The hepatitis B vaccine is generally given in the arm as a two-dose or three-dose series. For the three-dose series, the shots are given on a 0, 1, and 6-month schedule. For the two-dose series, the shots are given about a month apart. The World Health Organization (WHO) recommends that all infants receive the first dose of the hepatitis B vaccine within 24 hours of birth and complete the series with additional shots at 1 month and 6 months of age. This will ensure protection against hepatitis B for life.
The hepatitis B vaccine has been available since 1982, and over 1 billion doses have been used. It is composed of highly purified preparations of hepatitis B surface antigen (HBsAg), which is a glycoprotein that is a component of the envelope of the hepatitis B virus. The vaccine is made by harvesting HBsAg from the plasma of patients with chronic infection or by inserting plasmids containing the viral gene into yeast or mammalian cells. An adjuvant, such as aluminium phosphate or aluminium hydroxide, is added to the vaccines, which are sometimes preserved with thiomersal.
While vaccines, like any medicine, can have side effects, many people who get the hepatitis B vaccine experience no side effects at all. The most common side effects include injection site pain, soreness, or redness, headache, and fatigue, and they are usually mild and last 1-2 days. A review of reports of adverse events following hepatitis B vaccination from 2005 to 2015 did not detect any new or unexpected safety concerns. Additionally, scientific studies have concluded that the hepatitis B vaccination does not cause MS or other autoimmune conditions.
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Hepatitis B vaccine effectiveness
Hepatitis B is a liver disease caused by the hepatitis B virus (HBV). It is a common cause of viral hepatitis, with an estimated 250 million people living with chronic HBV infection globally. The infection causes nearly 900,000 deaths each year. The hepatitis B virus spreads through contact with contaminated blood and body fluids.
The hepatitis B vaccine is safe and effective, and it protects against hepatitis B in more than 95% of healthy infants, children, and young adults. The vaccine is given as an injection, generally in the arm, and is available as a two-dose or three-dose series. The three-dose series is given on a 0, 1, and 6-month schedule, while the two-dose series is administered with the doses one month apart. The World Health Organization (WHO) recommends that all infants receive the first dose of the hepatitis B vaccine within 24 hours of birth, followed by two or three additional doses to complete the primary series. This birth dose can effectively prevent mother-to-child transmission of the virus.
Vaccination is the primary tool for preventing hepatitis B infection. It is highly effective in preventing the spread of the virus and has significantly reduced the rate of chronic infection. In many countries, vaccination has decreased the rate of chronic infection among immunized children from 8-15% to less than 1%.
Completing the hepatitis B vaccine series is essential for ensuring protection against hepatitis B. It is recommended to begin the series at birth or as early as possible to ensure lifelong protection. For those who have missed a dose, it is important to get the next dose as soon as possible to maintain the effectiveness of the vaccine.
In addition to infants, the hepatitis B vaccine is recommended for unvaccinated children and adolescents under the age of 19, adults aged 19-59, and adults 60 and older with risk factors for hepatitis B. High-risk groups include people who frequently require blood or blood products, dialysis patients, recipients of solid organ transplants, and healthcare workers exposed to blood and blood products. Travelers to endemic areas are also advised to complete their hepatitis B vaccination before their trip.
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Who should get the hepatitis B vaccine?
The hepatitis B vaccine is recommended for people of all ages. The World Health Organization (WHO) recommends that all infants receive the first dose of the hepatitis B vaccine within 24 hours of birth. The vaccine series should then be completed with additional shots at one month and six months of age.
For those who missed out on the vaccine as infants, it is recommended that they receive the vaccine as children or adults. The Advisory Committee on Immunization Practices (ACIP) recommends the hepatitis B vaccination for unvaccinated children younger than 19 years of age, adults aged 19-59, and adults 60 and older with risk factors for hepatitis B.
In addition, certain groups may have a higher risk of exposure to hepatitis B and should consider getting vaccinated. This includes healthcare and public safety personnel who may come into contact with blood or blood-contaminated body fluids, people with diabetes (at the clinician's discretion), and international travelers to countries with high or intermediate levels of endemic hepatitis B virus infection.
The hepatitis B vaccine is safe and effective for pregnant women and can be administered as a two-dose or three-dose series, depending on the vaccine brand. It is important to complete the vaccine series as directed to ensure maximum long-term protection against hepatitis B.
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Hepatitis B vaccine availability
Vaccination is the best way to prevent hepatitis B infection. The hepatitis B vaccine is safe and effective, and it is recommended for people of all ages.
The hepatitis B vaccine is widely available at pharmacies and clinics. In the United States, the vaccine can be obtained at Walgreens and CVS Pharmacy. Vaccines offered at Walgreens vary by state, age, and health conditions, so it is important to talk to a local pharmacist about availability. CVS Pharmacy also offers the hepatitis B vaccine, and individuals can schedule their vaccination at a convenient location.
The hepatitis B vaccine is typically administered as a series of two or three shots, depending on the vaccine brand and the age of the recipient. The World Health Organization (WHO) recommends that infants receive their first dose of the vaccine within 24 hours of birth, followed by additional shots at one month and six months of age. For children and adolescents under the age of 19 who have not been vaccinated, the CDC recommends completing the vaccine series.
For adults, the recommended number of doses and schedule may vary. The CDC recommends hepatitis B vaccination for adults aged 19-59 and adults 60 and older with risk factors for hepatitis B. Adults 60 and older without known risk factors may also receive the vaccine. The Heplisav-B vaccine, a two-dose series approved in 2017, is recommended for adults aged 18 and older. The two doses are administered one month apart, and no booster dose is required for long-term protection.
It is important to note that individuals with a history of severe allergic reactions to any component of the hepatitis B vaccine should not receive the vaccine. Pregnant individuals should consult their doctors before receiving the vaccine.
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Frequently asked questions
The hepatitis B vaccine is recommended for all infants at birth, children up to 18 years, adults 19-59, and adults 60 and older with risk factors for hepatitis B.
The hepatitis B vaccine is generally given as a three-dose series on a 0, 1, and 6-month schedule. Alternative schedules may be considered, but a third dose at 6 months is needed for maximum long-term protection.
Yes, the CDC recommends catch-up vaccination for all adults younger than 60 who have not been previously vaccinated. The Heplisav-B vaccine, a 2-dose series, is approved for adults 18 and older.
The hepatitis B vaccine provides long-term protection against acute and chronic hepatitis B infection, which can lead to liver disease and cancer. It is safe and effective, and most people do not experience any side effects.


















