
The COVID-19 pandemic has resulted in the development and distribution of several vaccines to combat the SARS-CoV-2 virus. Vaccines are crucial in managing the coronavirus, and billions of doses have been administered globally since 2021. While there are different types of vaccines, such as mRNA and protein subunit vaccines, none of them contain the live coronavirus. These vaccines have undergone rigorous testing and safety standards, including large-scale clinical trials, to ensure their effectiveness and protection against severe disease and death. While mild side effects may occur, serious reactions are extremely rare, and vaccines do not increase the risk of death from non-COVID causes.
| Characteristics | Values |
|---|---|
| Number of COVID-19 vaccine doses administered globally since 2021 | 13 billion |
| COVID-19 vaccine safety | Continuously monitored by WHO and regulatory authorities |
| COVID-19 vaccine side effects | Mild, including fever, body aches, and soreness at the injection site |
| COVID-19 vaccine safety for pregnant or breastfeeding women | Safe, with no identified concerns for mothers or babies |
| COVID-19 vaccine safety for children | Safe for children as young as 6 months old |
| COVID-19 vaccine effectiveness | Reduces the risk of severe disease and death, but does not completely prevent infection or transmission |
| COVID-19 vaccine ingredients | Do not contain the live virus that causes COVID-19 |
| COVID-19 vaccine types | mRNA and protein subunit vaccines are currently available |
| COVID-19 vaccine brands | Pfizer, Moderna, and Novavax |
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What You'll Learn

COVID-19 vaccines do not contain the live virus
The first two approved vaccines, Pfizer-BioNTech and Moderna, use messenger RNA (mRNA) to instruct the body to build the coronavirus' signature spike protein. The presence of the spike protein prompts an immune system response, resulting in antibodies that can combat the coronavirus. The third authorized vaccine, Novavax, is a protein subunit vaccine. This means it uses a harmless piece of the COVID-19 spike protein to alert the immune system to recognize and fight the real COVID-19 virus.
Since 2021, more than 13 billion COVID-19 vaccine doses have been administered globally, and serious reactions are extremely rare. Data shows that people who receive COVID-19 vaccines are less likely to die from COVID-19 or related complications than those who are unvaccinated. Vaccination should not be delayed in anticipation of newer versions of the vaccine. Currently approved vaccines continue to protect against severe disease, and the risk of severe illness is significantly reduced in vaccinated individuals.
It is important to note that COVID-19 vaccines, like any medical product, can have side effects. However, the most common side effects are usually mild, such as soreness at the injection site, fever, or body aches. These symptoms typically resolve within a day or two and can be managed with rest, fluids, or pain-relieving medications. While it is still possible to get COVID-19 after vaccination, vaccinated individuals are more likely to experience mild or no symptoms compared to those who are unvaccinated.
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Vaccines are safe for pregnant and breastfeeding people
COVID-19 vaccines do not contain the live virus that causes COVID-19. The vaccines teach our immune systems how to recognize and fight the virus that causes COVID-19.
It is understandable that pregnant and breastfeeding people may have concerns about the safety of the COVID-19 vaccine for themselves and their babies. However, health organizations and experts worldwide, including the World Health Organization (WHO), the American College of Obstetricians and Gynecologists, and the CDC, recommend that pregnant and breastfeeding individuals get vaccinated against COVID-19.
The COVID-19 vaccine has been shown to be safe for pregnant and breastfeeding people and can provide important protection for both the parent and the baby. In the United States alone, over 160,000 women have received the vaccine during pregnancy, and in Canada, 40,000 pregnant women had their outcomes tracked with positive results. According to Dr. Money, a health expert, there is no evidence of any adverse effects or safety concerns in pregnant individuals compared to non-pregnant individuals. Additionally, there is no evidence of an increased rate of miscarriage related to the COVID-19 vaccine.
Pregnant individuals who receive the vaccine pass on protective antibodies to their unborn babies, providing them with some level of protection after birth. Similarly, breastfeeding mothers who get vaccinated may transfer antibodies through their breast milk, offering their babies some antibody protection.
It is important to note that the risk of severe illness from COVID-19 is higher during pregnancy, and vaccination can help prevent this. The COVID-19 vaccine has been shown to be safe and effective in preventing severe disease and death from COVID-19. Therefore, it is recommended that pregnant and breastfeeding individuals get vaccinated to protect themselves and their families.
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Vaccines are continuously monitored for safety
Vaccines are essential public health tools that help prevent millions of hospitalisations and deaths each year. They are also very safe, with serious negative side effects from vaccinations being extremely rare. However, side effects and adverse events do sometimes occur, so it is important to continually monitor vaccine safety. This is why governments have multiple systems in place to track vaccine safety.
In the United States, the Food and Drug Administration (FDA) is responsible for regulatory review of vaccine research and development. The FDA requires healthcare providers to report any death after vaccination to VAERS, even if it is unclear if the vaccine was the cause. The CDC's reporting requirements for vaccine providers are also important. The CDC and FDA work together with other federal agencies to monitor vaccine safety using several safety systems. The Vaccine Adverse Event Reporting System (VAERS) is an early warning system co-managed by the CDC and FDA that monitors for potential vaccine safety problems. The CDC has also established an early vaccine adverse event tracking system called the Monitoring System for Adverse Events Following Immunizations (MSAEFI).
The World Health Organization (WHO) also continuously monitors the use of COVID-19 vaccines to identify and respond to any safety issues that might arise. Regulatory authorities in different countries also perform this function. Before a vaccine is introduced, it must go through extensive and rigorous testing to ensure it is safe. Once a vaccine is in use, it must be continuously monitored to make sure it continues to be safe. This ongoing monitoring involves regular assessments and post-approval clinical studies to report on its safety and effectiveness.
The COVID-19 vaccines have undergone the most intensive safety analysis in U.S. history and continue to be monitored for safety, even after FDA approval, to make sure they continue to meet FDA's standards for safety and effectiveness. To date, the systems in place to monitor the safety of COVID-19 vaccines have identified anaphylaxis and myocarditis or pericarditis as serious types of adverse events following COVID-19 vaccination. Other rare events, such as Guillain-Barré syndrome (GBS), are also monitored for and studied.
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Vaccines do not affect or interact with your DNA
COVID-19 vaccines do not contain the SARS-CoV-2 virus and cannot give you COVID-19. They also do not affect or interact with your DNA in any way. This is because the vaccines do not enter the nucleus of the cell, where our DNA (our genetic material) is located, and therefore cannot change or influence our genes.
COVID-19 vaccines help our bodies develop immunity to the SARS-CoV-2 virus without us having to get the illness. Different types of vaccines work in different ways to offer protection. For example, mRNA vaccines use mRNA created in a laboratory to teach our cells how to make a protein that triggers an immune response inside our bodies. This immune response, which produces antibodies, is what helps protect us from getting sick from that germ in the future.
Protein subunit vaccines, such as Novavax, contain pieces (proteins) of the virus that causes COVID-19. These virus pieces are the spike protein. The vaccine also contains another ingredient called an adjuvant that helps the immune system respond to that spike protein in the future.
Regardless of the type of vaccine, the body is left with a supply of "memory" T-lymphocytes and B-lymphocytes that will remember how to fight that virus in the future. It typically takes a few weeks after vaccination for the body to produce these lymphocytes.
While COVID-19 vaccines are safe and effective, they may cause side effects in some people. These side effects are usually mild and may include soreness at the injection site, fever, headache, chills, body aches, nausea, or a sore arm. These symptoms usually go away within a day or two and can be managed by getting some rest, drinking fluids, or taking pain-relieving medications.
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Vaccines have been tested in large clinical trials
The COVID-19 vaccines have undergone extensive testing and evaluation in large-scale clinical trials to ensure their safety and effectiveness. These trials are crucial to determine how well a vaccine works and to identify any potential side effects. The trials for the COVID-19 vaccines involved tens of thousands of adults of diverse ages, races, ethnicities, and medical conditions. For example, the Pfizer-BioNTech vaccine, which has been approved in multiple countries, included a clinical trial with more than 40,000 participants, while the Moderna trial had around 30,000 participants.
In these trials, approximately half of the participants received the actual vaccine, while the other half were given a placebo, allowing for a controlled comparison. It is important to involve individuals who are most likely to benefit from the vaccine in the trials. For COVID-19, this includes older individuals, men, and those with comorbidities, as they are at a higher risk of severe disease and death.
The trials also need to be adaptable and diverse in terms of locations and populations to ensure the vaccine's effectiveness across different groups. This is crucial because the effectiveness of vaccines can vary due to factors such as different variants of the virus circulating in various parts of the world. The global collaboration and coordination among researchers, governments, and vaccine manufacturers in the development and testing of COVID-19 vaccines have been unprecedented.
The results from these large clinical trials are then independently reviewed to assess the safety and efficacy of the vaccine, following guidelines set by organisations such as the World Health Organization (WHO). Regulatory agencies in individual countries then make decisions about approving the vaccines and developing policies for their use. This rigorous process ensures that the COVID-19 vaccines are safe and effective for the public.
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Frequently asked questions
No, none of the COVID-19 vaccines being developed in the United States contain the virus that causes COVID-19.
Yes, while natural infection does provide some immunity, it is not known how long this lasts. The vaccine helps protect you for longer and against different variants.
Serious allergic reactions to the vaccine are rare. However, if you have a history of allergies, it is recommended that you consult your GP before getting vaccinated.
Yes, it is important to continue to follow current COVID-19 guidelines, even after receiving the vaccine. This includes wearing masks, social distancing, and regular hand washing.
























