
Yellow fever is a dangerous, potentially fatal disease caused by a virus transmitted by infected mosquitoes. The infection can range from mild to severe, and there is currently no cure or specific treatment. The yellow fever vaccine is a live, weakened form of the virus, and a single dose provides long-lasting protection for most people. While some countries require proof of vaccination, others simply recommend it for travellers. However, certain individuals may be at a higher risk of developing a severe reaction to the vaccine and should consult a healthcare provider before vaccination.
| Characteristics | Values |
|---|---|
| Who should get the vaccine? | The yellow fever vaccine is for anyone aged 9 months or older traveling to a virus-affected area. |
| How many doses are required? | A single dose of the vaccine provides long-lasting protection for most people. |
| How often should you get the vaccine? | A booster dose is not needed. However, travelers going to areas with ongoing outbreaks may consider getting a booster dose if it has been 10 years or more since their last vaccination. |
| Are there any side effects? | Yes, side effects from the vaccine are generally mild and include redness at the injection site, headaches, muscle aches, and low-grade fevers. |
| Are there any severe side effects? | In rare cases, the vaccine may cause a serious allergic reaction called anaphylaxis, which requires immediate medical attention. Other severe side effects include neurotropic disease and post-vaccinal encephalitis. |
| Is there a risk of contracting yellow fever in vaccinated areas? | Yes, there is still a risk of contracting yellow fever in vaccinated areas. The virus is transmitted by infected mosquitoes, and outbreaks can occur when mosquitoes infect primates, such as monkeys, and then carry the virus to humans in cities and other places. |
| Which countries require the yellow fever vaccine for entry? | Over 40 countries, including Peru, Brazil, and Nigeria, have some risk of yellow fever and may require proof of vaccination for entry. Certain countries may also require an International Certificate of Vaccination or Prophylaxis (ICVP). |
| Where can you get the yellow fever vaccine? | The yellow fever vaccine can only be administered at designated yellow fever centers, and a prescription is typically not required. |
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What You'll Learn

Who should get the yellow fever vaccine?
The yellow fever vaccine is recommended for people who are nine months old or older and are travelling to or living in areas at risk of the yellow fever virus, mainly in certain tropical countries in Africa and South America. The virus is transmitted by infected mosquitoes and cannot spread directly from person to person. It is estimated that 170,000 people catch the virus each year, causing about 60,000 deaths. Symptoms of the disease include fever, muscle pain, headache, loss of appetite, nausea, and vomiting. A small proportion of those infected will develop severe disease, including jaundice, dark urine, stomach pain, and problems with liver and kidney function. Half of those who develop severe disease will die within 7-10 days, and there is currently no specific treatment.
The vaccine is a live, weakened form of the virus, and a single dose provides long-lasting protection for most people. It is recognised by the World Health Organization as providing lifetime protection, but some countries still require proof of vaccination within the last ten years for entry. Certain countries may also require an International Certificate of Vaccination or Prophylaxis (ICVP) for entry. It is important to check the specific requirements of your destination country, as well as to talk to a healthcare provider to determine if you need the vaccine or a booster shot.
Those who are under nine months or over 60 years of age may need to consult a healthcare provider before receiving the vaccine, as side effects or drug interactions are more common in these groups. Other individuals who may need to consult a healthcare provider before vaccination include people with weakened immune systems, those who have had their thymus removed or have a thymus disorder, and those showing symptoms of HIV infection or with low CD4+ T-lymphocytes. While the vaccine is generally safe, some people may have an increased risk of developing a reaction, and a few people should not get the vaccine because they have a greater risk of developing a severe reaction.
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Country-specific requirements
Singapore:
All travellers with a travel history to countries with a risk of yellow fever transmission within the previous six days must present a valid yellow fever vaccination certificate upon arrival in Singapore. This requirement also applies to those with more than 12 hours of airport transit in these countries. Travellers without a valid certificate are liable to be quarantined for six days from the date of departure from the affected countries.
India:
Passengers travelling to and from yellow fever endemic countries are required to possess a valid yellow fever vaccination certificate issued by authorised centres in India. Those without a valid certificate may be quarantined until the certificate becomes valid or for six days from the date of the last possible exposure to infection, whichever comes first. The vaccination services are provided on a first-come, first-served basis, and the original passport is mandatory.
Other countries:
Some countries, such as those in Africa and South America, may require proof of yellow fever vaccination for entry. The World Health Organization (WHO) publishes a list of countries with a risk of yellow fever transmission, and travellers should refer to this list and the specific entry requirements of their destination countries. Healthcare professionals should consider destination-specific risks and individual factors when deciding whether to vaccinate travellers. The CDC provides country-specific information on yellow fever vaccine entry requirements and recommendations.
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Side effects and risks
The yellow fever vaccine is considered one of the safest vaccines. However, in recent years, it has been associated with rare adverse events, including serious and sometimes fatal complications. The yellow fever vaccine is a live, weakened form of the virus, and while it provides long-lasting protection for most people, side effects may occur in some individuals.
Side effects from the yellow fever vaccine are generally mild and common to most vaccines. These typically include redness at the injection site, fever, headache, nausea, joint and muscle pain, and low-grade fevers. Some people may also experience mild symptoms such as chills, vomiting, or diarrhoea. However, it is important to note that side effects can occur up to 30 days after receiving the vaccine, and more severe side effects may require immediate medical attention.
One of the most serious potential side effects of the yellow fever vaccine is anaphylaxis, a severe allergic reaction that can be life-threatening. Individuals with allergies, including food allergies, or those who are allergic to latex, should carefully consider the risks and consult their doctor before receiving the vaccine. Other serious side effects include neurotropic disease or post-vaccinal encephalitis, which has been observed more frequently in children. There have also been reports of disseminated disease in otherwise healthy individuals, resulting in high lethality.
The yellow fever vaccine is not recommended for infants younger than nine months of age due to an increased risk of encephalitis. Additionally, individuals over 60 or with weak immune systems are advised to consult a doctor before vaccination, as they may be at higher risk of experiencing side effects or drug interactions. For individuals with certain underlying conditions, such as those who have had their thymus removed or have a thymus disorder, the benefits of the vaccine should be carefully weighed against the potential risks.
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Where to get the vaccine
The yellow fever vaccine is only available from designated Yellow Fever Vaccination Centers. In the US, the yellow fever vaccine available is YF-Vax, produced by Sanofi Pasteur. It is a live-attenuated vaccine that provides effective protection against yellow fever.
You can get the vaccine at Walgreens, which offers the vaccine at select locations, depending on the state, age, and health conditions. You can also get the vaccine at Passport Health Travel Clinics, which has locations across the US. They work directly with nurses and doctors and provide the yellow fever vaccine without the need for a prescription or a visit to a PCP.
In the UK, you can get the Stamaril® yellow fever vaccine at designated yellow fever centres. You can follow the links on the Fit for Travel website to locate your nearest centre.
It is important to note that a single dose of the yellow fever vaccine provides lifetime protection for most people. However, some countries may still require proof of vaccination within the last ten years for entry. It is recommended to check the specific requirements for your destination country before travelling.
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How long does protection last?
The yellow fever vaccine is a live, weakened form of the virus. A single dose of the vaccine is safe and provides life-long protection against yellow fever for most people. The vaccine provides effective immunity within 10 days for 80-100% of people vaccinated, and within 30 days for more than 99% of people vaccinated.
The World Health Organization (WHO) recognises that the vaccine provides lifetime protection. However, some countries still require proof of vaccination within the last 10 years for entry. It is important to check with your travel specialist or healthcare provider before your trip to see if a second yellow fever immunisation is required.
Yellow fever vaccination is recommended for anyone aged 9 months or older who is travelling to or living in areas at risk of yellow fever in Africa and South America. Vaccination is not typically recommended for those under 9 months or over 60 years, who should consult a healthcare provider before vaccination.
While the vaccine provides life-long protection for most people, travellers going to areas with ongoing outbreaks may consider getting a booster dose if it has been 10 years or more since their last vaccination. This is because certain countries might require this to enter.
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Frequently asked questions
The yellow fever vaccine is recommended for anyone travelling to a virus-affected area, especially in South America and Africa. Some countries may require proof of vaccination or a medical waiver to enter.
The vaccine is available at designated yellow fever centres or clinics. You can find your nearest centre by checking with your local health department.
Side effects are generally mild and may include redness at the injection site, fever, headache, nausea, joint and muscle pain, or vomiting. In rare cases, more severe allergic reactions may occur.
A single dose of the yellow fever vaccine provides long-lasting protection for most people. However, a booster dose may be recommended every 10 years for those at continuous risk of exposure.
Individuals with weakened immune systems or specific medical conditions, such as an allergy to egg products or gelatin, should consult a healthcare provider before receiving the vaccine. Pregnant women and those over 60 years old should also seek medical advice.


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