
Polio is a serious infection that can cause paralysis and even death. The poliovirus vaccine is an active immunizing agent that protects against poliomyelitis (polio). In the US, the only polio vaccine that has been used since 2000 is the inactivated poliovirus vaccine (IPV), which is administered by injection. The oral poliovirus vaccine (OPV) is no longer used in the US due to the rare risk of causing polio in people with weakened immune systems. IPV is recommended for all infants from 6 to 12 weeks of age and provides protection against all three poliovirus types.
| Characteristics | Values |
|---|---|
| Types of polio vaccines | Inactivated poliovirus vaccine (IPV) and oral poliovirus vaccine (OPV) |
| Types of polio vaccines given in the US | Only IPV since 2000 |
| Types of polio vaccines not given in the US | OPV |
| Administration of IPV | Injection in the leg or arm, depending on the patient's age |
| Administration of OPV | By mouth as a liquid |
| Age to administer polio vaccine | Not recommended for infants younger than 6 weeks |
| Number of doses of polio vaccine | 4 doses |
| Age to administer doses of polio vaccine | 2 months, 4 months, 6 to 18 months, and 4 to 6 years |
| Interval between doses | At least 4 weeks |
| Side effects of IPV | Fever, pain, redness, swelling, fussiness, tiredness, fainting, allergic reaction |
| Side effects of OPV | Headache, belly pain, fever, diarrhea |
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What You'll Learn
- The polio vaccine is recommended for babies from 6 to 12 weeks old
- The inactivated poliovirus vaccine (IPV) is the only polio vaccine in the US since 2000
- The oral poliovirus vaccine (OPV) is no longer used in the US
- IPV provides at least 90% protection with two doses and 99% with three
- Polio vaccines are important because the disease still exists in other countries

The polio vaccine is recommended for babies from 6 to 12 weeks old
The polio vaccine is recommended for babies as young as 6 weeks old in the US. The vaccine protects against poliomyelitis caused by poliovirus types 1, 2, and 3. It is important to note that the polio vaccine is not recommended for infants younger than 6 weeks of age as antibodies received from their mothers before birth may interfere with the vaccine's effectiveness.
In the United States, the inactivated poliovirus vaccine (IPV) is the only polio vaccine that has been administered since 2000. IPV contains a killed or inactivated poliovirus and cannot cause polio. After receiving the IPV vaccine, the body's immune system produces antibodies that can recognise and fight off the poliovirus, providing long-lasting immunity. IPV is administered through injection, with four shots given at 2 months, 4 months, 6 to 18 months, and 4 to 6 years of age.
The oral poliovirus vaccine (OPV), on the other hand, is no longer used in the United States due to the rare risk of causing polio in individuals with weakened immune systems or those who are unvaccinated. OPV contains a weakened live vaccine and is typically given by mouth as a liquid. While OPV is no longer administered in the US, doses given before April 2016 can count toward a child's polio vaccination requirements.
The polio vaccine is crucial for preventing polio infection, which can lead to permanent paralysis and even death. While polio has largely disappeared from the United States due to successful vaccination programs, maintaining high vaccination rates is essential to prevent outbreaks and ensure herd immunity.
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The inactivated poliovirus vaccine (IPV) is the only polio vaccine in the US since 2000
The oral polio vaccine (OPV) is no longer used in the United States. OPV was discontinued in the US in 2000 due to the rare risk of causing polio in people with weakened immune systems or those who are unvaccinated. OPV is still used in several other countries as it is low-cost and easy to administer.
The inactivated poliovirus vaccine (IPV) is the only polio vaccine that has been administered in the US since 2000. IPV is safe and effective, offering 99-100% protection against polio with mild side effects such as soreness and fever. IPV is administered by injection in the arm or leg, depending on the patient's age. It is recommended that children receive four doses of IPV as part of their routine childhood immunisation schedule.
IPV is a single-antigen vaccine that protects against poliovirus types 1, 2, and 3. It contains a killed poliovirus, which means it cannot cause polio. After receiving IPV, the body's immune system produces antibodies that provide long-lasting immunity against the virus. IPV may also be administered in combination with other vaccines, such as Pentacel, Pediarix, and Kinrix.
It is important for children who have not started or completed their polio vaccination series to follow the recommended catch-up schedule. Additionally, adults who are unvaccinated or incompletely vaccinated should receive the necessary doses of IPV to complete their primary series. Individuals planning international travel, especially to areas with increased poliovirus exposure, should ensure they are fully vaccinated before departure.
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The oral poliovirus vaccine (OPV) is no longer used in the US
The switch from OPV to IPV occurred in the 1990s in many developed countries, including the US. OPV contains a weakened live vaccine, which carries a rare risk of causing polio in individuals who are not immunized or who have weakened immune systems. On the other hand, IPV contains a killed or inactivated poliovirus, eliminating the risk of vaccine-derived polio.
While OPV is no longer used in the US, it is still utilized in several other countries. OPV is given by mouth as oral drops and is advantageous due to its ease of administration, making it suitable for mass vaccination campaigns. Additionally, OPV provides longer-lasting immunity than IPV, as it confers both humoral and cell-mediated immunity.
In April 2016, a significant change occurred in the use of OPV worldwide. All countries that were still using trivalent OPV (tOPV) switched to using bivalent OPV (bOPV) in routine immunization. However, bOPV does not provide protection against type 2 poliovirus, leaving individuals vulnerable to this strain. This switch contributed to outbreaks of circulating vaccine-derived poliovirus type 2 (cVDPV2), with cases increasing from two in 2016 to 1037 in 2020.
To address this issue, a novel OPV2 vaccine (nOPV2) was developed and granted emergency licensing in 2021, followed by full licensure in December 2023. This new vaccine has greater genetic stability and is less likely to revert to a virulent form. Despite these advancements, the US continues to rely solely on IPV for polio vaccination, ensuring the elimination of the risk associated with vaccine-derived polio.
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IPV provides at least 90% protection with two doses and 99% with three
In the United States, the inactivated poliovirus vaccine (IPV) is the only polio vaccine that has been administered since 2000. It is given as a shot in the leg or arm, depending on the patient's age. The oral polio vaccine (OPV), on the other hand, is no longer used in the US due to the rare risk of causing polio in unvaccinated individuals or those with weakened immune systems.
The IPV vaccine is highly effective in preventing severe disease caused by poliovirus. Two doses of IPV provide at least 90% protection against the disease. This level of protection is significant and offers a strong defence against polio infection. While the exact mechanism may vary, the vaccine prompts the body's immune system to produce antibodies that can recognise and fight the poliovirus, thereby preventing severe illness.
However, the protection offered by the IPV vaccine increases substantially with an additional dose. Three doses of IPV provide at least 99% protection, which is an even more robust defence against the disease. This level of protection is crucial in ensuring that individuals are well guarded against the potentially devastating effects of polio, including paralysis and, in some cases, death.
The recommended number of doses for IPV varies depending on age and other factors. Children in the US are advised to receive four doses of IPV before starting school, with the option of a fifth dose if they are receiving certain combination vaccines. The timing between doses is also important, with the second dose typically administered 1 to 2 months after the first, and the third dose given 6 to 12 months after the second.
In summary, while two doses of IPV offer substantial protection against polio, receiving three doses provides an even higher level of defence, ensuring individuals are well-protected against this serious disease.
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Polio vaccines are important because the disease still exists in other countries
Polio is a highly infectious disease that has existed since prehistoric times and can lead to permanent paralysis and even death. The poliovirus attacks the nervous system, causing spinal and respiratory paralysis. The disease mostly affects young children. In the late 19th and early 20th centuries, frequent epidemics made polio the most feared disease globally, killing or paralysing over half a million people annually.
The polio vaccine is an injection that prevents poliovirus infections. It helps the body's immune system to learn how to fight off the virus, providing protection against severe disease caused by the poliovirus. Two doses of the vaccine provide at least 90% protection, while three doses offer at least 99% protection.
In the United States, the inactivated polio vaccine (IPV) is the only polio vaccine that has been administered since 2000. It is given to infants as young as six weeks old and is also available to children and adults. IPV is safe and effective, and it cannot cause polio. It is administered by injection in the leg or arm, depending on the patient's age.
However, polio still exists in other countries, and the risk of infection persists. The oral polio vaccine (OPV) is used in countries where the risk of infection is high because it is low-cost and easy to administer. OPV is given by mouth as drops or on a sugar cube. While OPV is safe and effective, it poses a risk of circulating vaccine-derived polioviruses (cVDPVs) in undervaccinated communities.
Therefore, it is important for individuals, especially children, to be fully vaccinated against polio, even in countries like the United States where the disease has been largely eradicated. Vaccination not only protects individuals from the potentially devastating effects of polio but also helps prevent the spread of the disease to unvaccinated populations in other parts of the world.
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Frequently asked questions
The polio vaccine protects against polio, a potentially serious disease that can lead to permanent paralysis and sometimes death. There are two types of polio vaccines: inactivated poliovirus vaccine (IPV) and oral poliovirus vaccine (OPV).
Yes, babies do get vaccinated for polio in the US. The CDC recommends immunization against polio for all infants from 6 to 12 weeks of age. The polio vaccine is not recommended for infants younger than 6 weeks old.
The only polio vaccine that has been used in the US since 2000 is IPV. OPV is no longer used in the US due to the rare risk of causing polio in people with weakened immune systems.
IPV is administered by injection into the muscle or under the skin. The number of shots varies, but children typically receive a total of 4 shots at 2 months, 4 months, 6 to 18 months, and 4 to 6 years of age.
Yes, as with any vaccine, there may be side effects. Mild side effects of IPV include fever, pain, redness, or swelling at the injection site. Babies and toddlers may also become fussy or tired. Serious reactions are rare but possible.











































